Real Madrid opened a 10-point lead over Barcelona at the top of La Liga after Cristiano Ronaldo's sixth hat-trick of the season clinched a 4-2 comeback win at home to 10-man Levante on Sunday.
Sevilla set up a King's Cup showpiece clash against Barcelona with a 6-2 aggregate semi-final victory over Celta Vigo after a 2-2 second-leg draw on Thursday.
West Ham had lost their first three Premier League games to sit bottom of the table and their dismal start to the campaign had already sparked speculation among pundits as to whether new manager Manuel Pellegrini would see out the season.
Joao Miranda and new signing Mario Mandzukic led Atletico Madrid to a 2-1 home win in La Liga on Saturday as visitors Eibar were unable to cope with the aerial threat of the champions.
Sevilla goalkeeper Sergio Rico blundered and then made two brilliant late stops as they were held to a 1-1 draw at Alaves on Monday that dented their La Liga title bid.
Victory in their first match on the league's resumption after the COVID-19 stoppage took basement team Espanyol to 23 points from 28 games, three points off the safety zone.
Simeone's side leapfrogged Real Sociedad into fourth on 42 points, while Sevilla stayed third in the standings on 46 after beating Las Palmas 1-0, also on Sunday, thanks to a late strike from substitute Joaquin Correa
Prolific Cristiano Ronaldo hit a 35th hat-trick for Real Madrid who swept aside Espanyol 6-0 in a ruthless attacking display in La Liga on Sunday.
Two goals from Arda Turan and one from Lionel Messi gave Barcelona a 3-0 win over Sevilla in the Spanish Super Cup second leg on Wednesday to seal a 5-0 aggregate victory.
James Rodriguez headed the opener before going off injured in Real Madrid's win.
Real Madrid set a Spanish record of 40 matches unbeaten in all competitions after they came back from two goals behind to snatch a 3-3 draw at Sevilla with a last-gasp equaliser from Karim Benzema in the King's Cup on Thursday.
Champions Barcelona suffered their second defeat in three matches in La Liga on Saturday, with Michael Krohn-Dehli scoring and setting up another goal in a 2-1 victory for Sevilla.
Liverpool cranked up the pressure on West Ham United manager Slaven Bilic with a 4-1 victory at the London Stadium, while Burnley's remarkable start to the Premier League season continued thanks to a 1-0 victory at Southampton on Saturday.
News of all that's transpired on and off the football field
La Liga's reputation as the epicenter of world soccer talent has been bruised by the world record smashing sale of Neymar to Paris St Germain and how Barcelona react to the departure of one of their leading players will define the new season in Spain.
Real Madrid clinched a record-extending 34th La Liga title with one game to spare by beating Villarreal 2-1 at home on Thursday thanks to two goals from their leading scorer Karim Benzema. Real have 86 points after 37 games, seven more than deposed champions Barcelona who were beaten 2-1 at home to Osasuna.
IMAGES from the Europa League matches played on Thursday
Messi stretched Barca's lead by finishing off a brilliant move with Luis Suarez in the 50th minute and the Uruguayan joined his close friend and strike partner on 15 league goals by robbing an Eibar defender and finishing inside the near post in the 68th.
Images from matches played across European leagues on Saturday
Real Madrid's Javier Hernandez struck twice as they came from behind to beat Celta Vigo 4-2 away and keep the pressure on Barcelona at the top of La Liga on Sunday.
Fiorentina tore apart Italian rivals AS Roma to reach the Europa League quarter-finals with a 3-0 win that left their opponents' season in tatters and under-fire coach Rudi Garcia tottering on the brink of the sack.
La Liga leaders Real Madrid dropped points at home for only the second time this season.
Sevilla's Kevin Gameiro grabbed a late equaliser in a 2-2 draw at Zenit St Petersburg on Thursday to send the Europa League holders into the semi-finals after woeful goalkeeping had threatened to ruin their night.
Liverpool's Egyptian forward Mohamed Salah scored his 29th Premier League goal six minutes from time to secure a 2-1 win at Crystal Palace that took them up to provisional second spot in the table on Saturday.
Liverpool manager Juergen Klopp enjoyed a satisfying return to Borussia Dortmund as his new side frustrated his former charges and claimed a valuable away goal to draw 1-1 in their Europa League quarter-final, first leg on Thursday.
IMAGES from the La Liga matches played on Tuesday
Luis Suarez scored a hat-trick and Lionel Messi bagged a brace as Barcelona thrashed bottom side Cordoba 8-0 on Saturday to move a step closer to their fifth La Liga title in seven years.
IMAGES from the English Premier League matches played on Saturday
A summary of Saturday's matches in the English Premier League.
Images from the English Premier League matches played on Saturday
Photographic summary of the football matches played across Spain, Italy and France
News of all that's transpired on and off the football field
An Aaron Ramsey strike and a Kalidou Koulibaly own goal gave Arsenal a 2-0 victory over Napoli in the first leg of their Europa League quarter-final, while Chelsea beat a stubborn Slavia Prague 1-0.
Photos from the Champions League matches played across Europe on Tuesday